Base diactivated columns are columns with reduced silanol activity/plar interactions towards bases (amine, amidines, etc.) which have tendency. This is achieved by end capping or other means. Just do a search on Google with key words base+deactivated+columns.
“Base deactivated stationary phases generally provide better peak shape, increased column efficiency, and improved lot-to-lot reproducibility when separating polar compounds. They have been particularly useful in improving the separation of samples containing basic compounds. However, there are occasions when typical base deactivated phases lack adequate selectivity.
Manufacturers of base deactivated columns try to minimize polar-polar interactions between analytes and the stationary phase. Because of this, most base deactivated columns have similar selectivity for polar compounds. This means that if one brand of base deactivated column lacks selectivity to adequately separate a pair of polar solutes, other brands of base deactivated columns will also probably lack adequate selectivity for these solutes.
Stationary phases that permit polar-polar interaction through silanol activity offer alternate selectivity to base deactivated phases, but it often comes at a cost of poor peak shape and uncertain reproducibility. The ProntoSIL C18 EPS solves this problem by providing both enhanced polar selectivity and excellent peak shape (Figure 1).â€
