per aquous liquid chromatography PALC

[sofiane]

hello
can you tell me about the sensitivity of PALC with a MS detector

what about HILIC

thank you

[sav]

Hi,
ESI: A(PALC) < A(HILIC); A - "sensitivity"

[sofiane]

thank you sav

is this ruller general ?
is the difference high ?

[sav]

is this ruller general ?

Yes (ESI)

is the difference high ?

The difference is very high in some cases. See theory of ESI (etc.)

"Sensitivity" of analytical system (LC-MS etc.) depend on many factors (method of ionization, ms-parameters, lc-parameters...). Answer to the question is much more difficult for other methods of ionization.