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DMSO as HPLC solvent

http://www.chromforum.org/viewtopic.php?t=18232

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DMSO as HPLC solvent

Posted: Mon Nov 14, 2011 4:58 pm
by jiangds06
just curious of strength of DMSO as mobile phase compared to MEOH and ACN?

Re: DMSO as HPLC solvent

Posted: Tue Nov 15, 2011 8:05 am
by unmgvar
80% DMSO compares to 100% methanol
102.6% DMSO is like 100% ACN

Re: DMSO as HPLC solvent

Posted: Tue Nov 15, 2011 3:26 pm
by HPLCaddict
...but I think you won't be happy about the backpressure it generates. Isn't DMSO quite viscous?

Re: DMSO as HPLC solvent

Posted: Fri Nov 18, 2011 3:19 pm
by jiangds06
I just want to use this solvent for spe elution.
...but I think you won't be happy about the backpressure it generates. Isn't DMSO quite viscous?

Re: DMSO as HPLC solvent

Posted: Fri Nov 18, 2011 8:17 pm
by carlos.teixeira
Dear jiangds06,

However DMSO can be nice for your HPLC method considere, please, this solvent may give serious headache since its high viscosity is able to increase pressure system. By other way, for diluted concentration, go ahead.

All the best and have nice elutions!

Carlos Teixeira
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