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per aquous liquid chromatography PALC
Posted: Sun Nov 13, 2011 9:03 pm
by sofiane
hello
can you tell me about the sensitivity of PALC with a MS detector
what about HILIC
thank you
Re: per aquous liquid chromatography PALC
Posted: Mon Nov 14, 2011 2:59 pm
by sav
Hi,
ESI: A(PALC) < A(HILIC); A - "sensitivity"
Re: per aquous liquid chromatography PALC
Posted: Mon Nov 14, 2011 7:02 pm
by sofiane
thank you sav
is this ruller general ?
is the difference high ?
Re: per aquous liquid chromatography PALC
Posted: Tue Nov 15, 2011 4:19 pm
by sav
is this ruller general ?
Yes (ESI)
is the difference high ?
The difference is very high in some cases. See theory of ESI (etc.)
"Sensitivity" of analytical system (LC-MS etc.) depend on many factors (method of ionization, ms-parameters, lc-parameters...). Answer to the question is much more difficult for other methods of ionization.