Chromatography Forum

Hi everyone!
I'm looking for one method to determine a possible sodium acetate impurity in my sample. It's just an option, we are not sure of this impurity.
To analyze my sample, I'm working with a Symmetry C8, ammonium acetate buffer pH=3 and a mixture acetonitrile/methanol as organic solvent. Wavelength is dual: 220 and 254nm.

Is there any option to detect sodium acetate with these conditions?

Thanks!!!

B.

No. You will need a totally different method.

And, how can I start?? Could it be better with GC??

If there is no other source of sodium in your sample, it might be easiest to analyze that (ion-selective electrode? ion chromatography?). If there are no other major anions, then spe followed by ion chromatography or spe followed by GC?

Sodium is easily determined by atom absorbtion spectrscopy (graphite furnace or flame) or ICP.
For acetate there are numerous HPLC applications online.