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Poor Reproducibility of readings from the IC

http://www.chromforum.org/viewtopic.php?t=17935

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Poor Reproducibility of readings from the IC

Posted: Thu Oct 13, 2011 12:49 am
by Chromatography
Hi All,

I am having trouble obtaining the same readings for the same samples being run for cations on the IC. The readings tend to increase as more samples are run. Does anyone know of why this is happening?

Thanks :)

Re: Poor Reproducibility of readings from the IC

Posted: Thu Oct 13, 2011 11:49 am
by tom jupille
Can you be a *bit* more specific?
What instrument (manufacturer/model)?
What column / mobile phase?
What kind of suppressor?
Are the retention times changing or only the peak areas?
How much variation are you seeing?
How suddenly did the problem begin?
Did the onset of the problem coincide with some specific event (instrument service? new batch of mobile phase?)?
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