pump seal failure

[mirac_han]

ı have been working in agilent 1200 systems. my method is containing reversed phase solvents.

ı change my pump seal every 3 or 5 mounths. ı think this time span is lower life for pump seal. ıt reduces a big cost for our. my shut down method containing a acetonitrille. ı red a article about pump seal ' higher acn value can reduce pump seal because acn to wet the pump seal surface than meoh'

what is the possible cause this problem?

thanks every body.

[tom jupille]

Check with Agilent regarding their recommendations for seals. In my experience, premature seal failure is more often associated with leaving buffer-containing mobile phases in the pump at shut down (as opposed to flushing the buffers out of the pump), so a shut-down with ACN is generally a good idea.