Quantification of Esters by GC-MS

[Murugan Saravanan]

Hi colleagues,
I'm new to this forum. Lot of good discussions are happening in this forum. I want to pose one question to get more clarity. Can any one help me to find out some resources/literature of method of analysis of residual esters in pharmaceutical drugs. The level expected is around 1 µg/g based on the drug daily dosage.
I appreciate the comments in advance.
Warm Regards
Murugan Saravanan

[chromatographer1]

Are you discussing small molecular weight esters, like methyl or ethyl acetate, formates?

Or are you referring to large molecule esters where the esterified acidic functional group is a minor component?

One might be done by headspace analysis and the other might require a thin film moderate polarity phase capillary column.

A search on Chem Abstracts might be helpful.

While desiring a little clarity your question is quite cloudy concerning your goal, at least, it is to me.

Can you give a little specificity to the esters you wish to discuss?

best wishes,

Rod

[Murugan Saravanan]

Thanks, Rod, for your reply. I meant small molecules where testing of sulphonic esters of methyl, ethyl, isopropyl groups is essential. These can be formed when sulphonic acids reacts with the solvents like methanol, ethanol & IPA being used in the mfg. process. As these sulphonic esters are classified as genotoxic, the residual content in the parent drug is quite challenging.
Regards
Murugan Saravanan