Volatile salts (buffer)

[Hollow]

Just for curiosity:

Does anybody know what effects/conditions makes buffer salts like e.g. ammonia formate, -carbonate etc. volatile?

Is it more the temperature or the vapor pressure (vacuum)?

-> Comparison between the application of such buffers in LC/MS vs. (semi)-prep LC.

--> Can the usual temperature and vaccum of a rotavap be enough to get rid of such salts or does it need higher temperature as in LC/MS probes?

[Kostas Petritis]

You might be interested at a paper I wrote back in graduate school where I tested different acids, bases and their salts at different concentration and used an evaporative light scattering detector (ELSD) to test their volatility (see link below). Figure 1 can maybe respond to some aspects of your question. TFA salts were less volatile than formate and acetate. I still like that paper and refer to it time to time...


http://chromatographyonline.findanalyti ... etail/9090