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Specificity study for Related substances by GC method
Posted: Thu Mar 17, 2005 3:00 am
by bhaskarac
Can anybody give suggestion how to perform the specificity study when we are performing method validation for related substances by GC method.
Thanks in advance
Posted: Mon Mar 21, 2005 4:56 pm
by Mark
We inject a solvent blank, then each inpurity is injected separately and all in combination to check for specificity. If you are doing this from a formulated product you might want to inject any excipients that could make it to the GC also. Not forgetting to inject the analyte of interest also.
Regards,
Mark
Posted: Tue Mar 22, 2005 5:11 pm
by A.Nonymous
What with stress conditions (eg acid, alkaline, oxidation, temperature,...)?