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Separation of Na salt of p- Cresol with p- cresol
Posted: Sun May 22, 2011 5:10 pm
by praveenpaliwal
Hellow every body,
I want to separate Sodium salt of p cresol & P cresol. Is it possible with derivatization by chloroacetyl chloride??? If no then what is the suitable derivatization agent.
Best regards
Praveen
Re: Separation of Na salt of p- Cresol with p- cresol
Posted: Sun May 22, 2011 6:59 pm
by Don_Hilton
My thought would be to partition the analytical mixture between mild, aqueous acid and an organic solvent (like toluene) and then derivatize to ensure the presence of salts does not cause a problem. I tend to like MSTFA as a reagent for phenols, catechols, and such, but chloroacetyl chloride will probably work - I would add some dry pyridine remove the acid from the reaction.
Re: Separation of Na salt of p- Cresol with p- cresol
Posted: Mon May 23, 2011 8:40 am
by HW Mueller
One will shift equilibrium with the partition, in the other chain on this the answer was given , I think by Vlad.
Re: Separation of Na salt of p- Cresol with p- cresol
Posted: Mon May 23, 2011 11:05 am
by Don_Hilton
Reading this question first in the GC questions, I read the question as sepration of both compunds from matrix rather than from each other. The sodium salt will not be seen in the GC - at least as the sodium salt. I gave an answer that wouild separate the cresol and cresol salt from other things in the matrix...