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Suitable mobile phase

Posted: Fri Apr 15, 2011 2:10 am
by mkhalidp
Dear all

I need to develop a LC-MS/MS method for two comopunds,comppound A having Pka of 4.2 and compond B having Pka of 8.3. Can you suggest a suitable mobile phase to separate these two compounds with high variability in their PKa values.

Regards
Kp