peak fronting at higher temperature
Posted: Tue Apr 05, 2011 1:57 pm
I was wondering if anyone could speculate on why I observe fronting at higher temperatures for one peak.
The peak is likely a cation, a related substance of a ''''pril type drug. It also has a carboxyl group. The column is a phenomenex polar rp (phenyl) column using 99% [0.1%TFA aq] 1% MeOH.

this is at 35C

at 50C
The peak is likely a cation, a related substance of a ''''pril type drug. It also has a carboxyl group. The column is a phenomenex polar rp (phenyl) column using 99% [0.1%TFA aq] 1% MeOH.

this is at 35C

at 50C