Paracetamol and Codeine phosphate Impurity determination

[Chokshi Mahesh]

Can anybody suggest HPLC method for the simultaneously determination of Paracetamol and Codeine phosphate impurities. Strength 8/500.

[dorota]

Journal of Pharmaceutical and Biomedical Analysis
Volume 26, Issues 5-6, December 2001, Pages 857-864

LC method for the analysis of paracetamol, caffeine and codeine phosphate in pharmaceutical preparations
Murat Kartal

[dorota]

http://www.pharmpress.com/shop/samples/ ... sample.pdf
http://ff.unair.ac.id/abstractskripsi/doc/050312704.doc

[Chokshi Mahesh]

Thanks dorota for your reply.

But my requirement is Related substances method.

Problem is if we are trying to get 10000 ppm concentration of codeine phosphate (as mentioned in EP monograph Acetaminophen concentration will be 6250000, I am concern about this much high concentration)