chromatography
Posted: Fri Mar 11, 2011 4:26 am
I want know that Amlodipine besylate is incompatible with gelatin is it true?
Chromatography Forum
Chromatography Forum is a public discussion group where you can post questions, news, or messages of interest to chromatographers everywhere, but you must be registered to participate (registration is FREE). If you are a registered user, please log in.
http://www.chromforum.org/
chromatography
Page 1 of 1
Re: chromatography
Posted: Fri Mar 11, 2011 4:30 am
A quick look on the internet indicates the two occur togehter in dosage forms.
Re: chromatography
Posted: Sun Mar 13, 2011 5:05 pm
I think the topic is kind of incompatible with the question 
Re: chromatography
Posted: Sun Mar 13, 2011 5:49 pm
I've been waiting for the explanation of the chromatography question that was intended....
Re: chromatography
Posted: Mon Mar 14, 2011 2:13 am
In patent called "stable pharmaceutical compositon containing amlodipine besylate and atenolol" describes that Amlodipine besylate was found to be incompatible with gelatin, PVP, Hydroxy propyl cellulose, sodium alginate.
in our formulation we get contineously decrease in assay value of amlodipine under accelarated conditions and it is not reflected in related substance determination, so there might be chances of non chromophoric impurity generation so, i have asked that question on basis of the patent tht any body is in experience with this kind of problem.
this is innovative for me because i think it is better to solve simple problems
thanks all
in our formulation we get contineously decrease in assay value of amlodipine under accelarated conditions and it is not reflected in related substance determination, so there might be chances of non chromophoric impurity generation so, i have asked that question on basis of the patent tht any body is in experience with this kind of problem.
this is innovative for me because i think it is better to solve simple problems
thanks all