Chromatography Forum

Hai Friends,
Can anybody suggest an HPLC method for Ziprasidone Hcl.
I am trying with triethylammonium phosphate buffer ,acetonitrile in different ratios and with C18 and C8 columns. Compound is eluted but an impurity at tailing is not getting resolved. I could not give correct % of this impurity
Also I tried with TBAHS as buffer and acetonitrile. Though I could not resolve the sample.

Regards

Raman

El-Sherif ZA, El-Zeany B, El-Houssini OM, Rashed MS, Aboul-Enein HY.
Stability indicating reversed-phase high-performance liquid chromatographic and thin layer densitometric methods for the determination of ziprasidone in bulk powder and in pharmaceutical formulations. Biomed Chromatogr. 2004 Apr;18(3):143-9

Method given in abstract;
http://www.ncbi.nlm.nih.gov/entrez/quer ... s=15103698

Good luck

Ann