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HILIC mode in LC/MS

http://www.chromforum.org/viewtopic.php?t=15967

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HILIC mode in LC/MS

Posted: Fri Mar 04, 2011 3:36 am
by thohry
Hi all,

I just use HILIC mode for analyzing melamine by LC/MS. I have read the HILIC mode is a good choice for LC/MS. I can see the LC buffer is suitable for MS. What is the reason other than that ?

Thanks for any input.

Thohry.

Re: HILIC mode in LC/MS

Posted: Fri Mar 04, 2011 7:38 am
by Gaetan Glauser
Polar compounds elute at a high percentage of organic solvent in HILIC mode (50-95%), thus increasing the sensitivity of the MS.
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