MS compatibility of additives
Posted: Tue Jan 25, 2011 7:29 pm
by LCFlo
Hello,
are mobile phases that contain TFA or triethylamine acetate compatible to MS detection?
Thank you very much for your advice
Regards
Florian
Re: MS compatibility of additives
Posted: Tue Jan 25, 2011 11:14 pm
by tom jupille
Yes they are compatible (in the sense that they are volatile). I think many LC-MS people prefer to avoid them because they can interfere with ionization (TFA) and can be *very* difficult to clean from systems. The results of a search on the MS board may give you some idea:
search.php?keywords=%2Btriethylamine+%2 ... mit=Search
Re: MS compatibility of additives
Posted: Wed Jan 26, 2011 2:00 pm
by HPLCCONSULT
Try Formic Acid instead of TFA.
0.1% is usually fine. It will not cause as many problems in the MS as TFA will.