MS compatibility of additives

[LCFlo]

Hello,

are mobile phases that contain TFA or triethylamine acetate compatible to MS detection?

Thank you very much for your advice

Regards

Florian

[tom jupille]

Yes they are compatible (in the sense that they are volatile). I think many LC-MS people prefer to avoid them because they can interfere with ionization (TFA) and can be *very* difficult to clean from systems. The results of a search on the MS board may give you some idea:
search.php?keywords=%2Btriethylamine+%2 ... mit=Search

[HPLCCONSULT]

Try Formic Acid instead of TFA.
0.1% is usually fine. It will not cause as many problems in the MS as TFA will.