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Software to scale up HPLC method
Posted: Thu Dec 16, 2010 3:16 pm
by joshisushil15
How can i get the software (Free) for scaleup of analytical HPLC method to prep HPLC. or calculation involved
PLease advice .
Re: Software to scale up HPLC method
Posted: Thu Dec 16, 2010 4:42 pm
by danko
You don't need a software for that. It takes shorter time to figure it out utilizing a simple pocket calculator than booting a PC.
You might like to describe the case here and I'm sure you'll get a lot of responses.
Best regards
Re: Software to scale up HPLC method
Posted: Fri Dec 17, 2010 3:35 pm
by Gaetan Glauser
As Danko said, calculation for geometrical transfer of HPLC conditions is really simple, however if you really wish to use a soft, check this out:
http://www.unige.ch/sciences/pharm/fana ... gement.htm
Re: Software to scale up HPLC method
Posted: Fri Dec 17, 2010 4:01 pm
by joshisushil15
Thanks for the response n the link.
Actually, I want to isolate the N-formyl deacetyl thiocolchicoside from the API thiocolchicoside by prep HPLC.
please suggest in this regard
thanks in advance
Re: Software to scale up HPLC method
Posted: Fri Dec 17, 2010 9:00 pm
by danko
Now I understand you need a real intuitive software.
Or a mind reader
What happend to the upscaling job
Best Regards
Re: Software to scale up HPLC method
Posted: Sat Dec 18, 2010 2:07 am
by joshisushil15
the resolution between these two compounds is very small in analytical method developed. I m not getting the proper resolution on upscaling.
Thatswhy i need the calculation/software for upscaling to prep and isolating the impurities.