Anybody having experience with spme and 2-hydroxyibuprofen. I have to develop a method for this and other compounds (ibuprofen, triclosan and salicylic acid). The other compounds seem to work well with a polyacrylat fiber but I get no peak for 2-hydroxyibuprofen. If I inject a std-solution directly I see nice peak. Do I have to derivatize somehow? :wink: