Chromatography Forum

Posted: **Tue Oct 26, 2010 12:29 pm**

Why NaOH, HCl, peroxide use for degradation?

Thanks in advance,
Ajay

Posted: **Tue Oct 26, 2010 7:30 pm**

Many reasons I imagine;
drug will likely come into contact or be in an environment that is acidic, basic or oxidising, this will show you what the products of that will be and then toxicity studies can be done on those products

Posted: **Wed Oct 27, 2010 6:54 am**

Hi
not to forget defined lux requirements etcetera, you can find further information at www.ich.org under the Q tab, in the various ICH Q1 guidelines.

Posted: **Fri Oct 29, 2010 11:47 pm**

NaOH/HCl - To evaluate stability with respect to pH

H2O2 - To evaluate susceptibility to oxidation

Chromatography Forum

Forced degradation

Forced degradation