MATRIX EFFECT IN GC/NCIMS
Posted: Wed Feb 02, 2005 7:14 am
Dear colleagues,
we are currently evaluating the use of GC/NCIMS to analyse PCB and OCP and are confronted with a rather strange observation. When we inject prepared samples (soil, water as well as QCS) the response of compounds as well as internal standards augments depending on the matrix injected. For the PCB this is not a real problem since the effect is outbalanced by the use of labelled homologues. The OCP is a different story: since standards are rather expensive using them at full is out of the question. Limiting the problem (if not inherent to the technique) is therefore my objective.
Has anyone encountered this problem already and/or has a solution o solve/bypass it?
instrument: Finnigan DSQ
CI-gas: NH3
inj: PTV
Sincerely,
Joeri Vercammen
we are currently evaluating the use of GC/NCIMS to analyse PCB and OCP and are confronted with a rather strange observation. When we inject prepared samples (soil, water as well as QCS) the response of compounds as well as internal standards augments depending on the matrix injected. For the PCB this is not a real problem since the effect is outbalanced by the use of labelled homologues. The OCP is a different story: since standards are rather expensive using them at full is out of the question. Limiting the problem (if not inherent to the technique) is therefore my objective.
Has anyone encountered this problem already and/or has a solution o solve/bypass it?
instrument: Finnigan DSQ
CI-gas: NH3
inj: PTV
Sincerely,
Joeri Vercammen