will TFA reduce load capacity for neutral compoudns

[jiang295]

as TFA occupy some C18 surface, I doubt it will decrease load capacity for neutral compounds somehow.....

[Uwe Neue]

No.

[jiang295]

could you elaborate a little bit:) thanks

No.

[Uwe Neue]

Neutral compounds are retained better and largely independently of TFA. I can't see why TFA would interfere with neutral compounds, especially at high loads.