Chromatography Forum

Posted: **Thu Aug 12, 2010 5:37 am**

Dear All

Why there is no separation for the polyethylene glycol (PEG) in GC? Is that due to the high molecular weight itself? Is any method can use to separate it?

Thanks & Regards
Pang

Posted: **Thu Aug 12, 2010 5:56 pm**

If it's a small enough PEG, one can obtain GC separation readily. We make trimethylsilyl derivatives here, use nonpolar capillaries.

Posted: **Fri Aug 13, 2010 10:08 pm**

Flash chromatography and thin layer chromatography can separate a molecular weight distribution of PEG. If the MW is too high it is not volatile enough to elute from a GLC column or the temperatures required are too high.

best wishes,

Rodney George

Chromatography Forum

Separation polyethylene glycol

Separation polyethylene glycol