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HILIC of nitriles

http://www.chromforum.org/viewtopic.php?t=13391

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HILIC of nitriles

Posted: Wed Jul 14, 2010 4:53 pm
by yaakov
Can I use HILIC in order to analyze alyphatic nitriles?
For instanse TMSN- tetramethylsuccinonitrile.

Posted: Thu Jul 15, 2010 8:20 am
by Bintang
I doubt it, especially using acetonitrile in the eluent. Your nitrile will likely not partition from an acetonitrile rich phase into a water rich one.
Could possibly work using acetone or some other exotic (for HILIC) organic solvent.

Posted: Sat Jul 17, 2010 10:17 pm
by unmgvar
what is your K using a RP column?

based on this example product why choose HILIC?
have you thought of going for a column that separate based on the effect to the Pi orbits.
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