MS-Compatibility of ion-pairing reagents

[LCFlo]

Dear all,

is octanesulfonic acid ammonium salt compatible for MS?

Thank you

Florian

[lmh]

My experience is that ion pair reagents with more than trivial lengths of hydrophobic chain can be very difficult to remove from MS systems (i.e. expect a background signal of an acidic ion pair reagent to remain visible in negative mode for some time). Use any ion pair reagent with caution.

[Bryan Evans]

I'd recommend looking at different stationary phases.

Below are antidepressants separated on Scherzo SM-C18 (C18 + anion ligand + cation ligand):
http://www.imtaktusa.com/site_media/fil ... TI525E.pdf

Retention for bases (ionic interaction) increases as eluent pH increases.