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what happen if length of alkyl chain decrease

Posted: Tue Apr 13, 2010 3:35 pm
by jiang295
if I decrease alkyl chain from C18 all the way to C1 chain, what will happen to the analyte retention time?
I know hydrophobic analyte will decrease, but how about hydrophilic analyte, will them increase?
will them like C1 column become normal phase column if we still use MEOH/H2O.



Deshou