LCMS ion pair reagents help

[scienceismylife]

Does anyone know if ethane sulfonic acid is LCMS compatible as an ion pair reagent? If not could anyone make a suggestion as to a good ion pair reagent for LCMS/UV use at 205 nm? Thank you for you help

[kerri]

Will you us in positive or negative mode?

[scienceismylife]

The instrument gets used in both modes, but mainly positive. This analysis will be preformed in positive ion mode.

[tom jupille]

The longer-chain alkyl sulfonates are widely considered to be non-volatile, but I don't know about the C2 (I suspect it won't work). The usual suspects for MS work are HFBA or TFA, neither of which is a good choice for UV below about 210 nm. I'm not sure you're going to be able to find a dual-purpose negative-charge IP reagent.

If it were my problem, I'd go with one of the evaporative detectors for the non-MS work.

[Kostas Petritis]

All suflonic acids are not-volatile and thus not compatible with the MS...

[scienceismylife]

Thank you all very much for the help