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LCMS ion pair reagents help
Posted: Mon Feb 15, 2010 9:38 pm
by scienceismylife
Does anyone know if ethane sulfonic acid is LCMS compatible as an ion pair reagent? If not could anyone make a suggestion as to a good ion pair reagent for LCMS/UV use at 205 nm? Thank you for you help
Posted: Sat Feb 20, 2010 3:21 pm
by kerri
Will you us in positive or negative mode?
Posted: Mon Feb 22, 2010 2:05 pm
by scienceismylife
The instrument gets used in both modes, but mainly positive. This analysis will be preformed in positive ion mode.
Posted: Mon Feb 22, 2010 5:43 pm
by tom jupille
The longer-chain alkyl sulfonates are widely considered to be non-volatile, but I don't know about the C2 (I suspect it won't work). The usual suspects for MS work are HFBA or TFA, neither of which is a good choice for UV below about 210 nm. I'm not sure you're going to be able to find a dual-purpose negative-charge IP reagent.
If it were my problem, I'd go with one of the evaporative detectors for the non-MS work.
Posted: Mon Feb 22, 2010 9:48 pm
by Kostas Petritis
All suflonic acids are not-volatile and thus not compatible with the MS...
Posted: Tue Feb 23, 2010 9:59 pm
by scienceismylife
Thank you all very much for the help