Peak Interference

[iventurina]

Hi! I am working on a moxidectin sample for DP analysis. The product contains polysorbate 80 and it is interefering with some of the known impurities. Anyone who can help me how to elliminate this intereferce? I have already tried woring on different gradient methods and column combinations. Any suggestions? Thanks

[tom jupille]

Probably best to eliminate it as part of sample workup. SPE perhaps?

[Kromatographer]

Hey were you ever able to figure out the moxidectin DP analysis?

Also wondering about the raw material early eluting impurities? The SST is pesky