GC-FID (Response factor for hydromorphone)

[Marko Bokhanovskyi]

My current task is to quantitatively determine hydromorphone using GC-FID. Unfortunately, authentic hydromorphone standard is unavailable. However, I do have a morphine reference standard.

Could you confirm if the effective carbon number (ECN) concept is applicable in this context? If so, I would appreciate assistance in calculating the predicted response factor for hydromorphone concentration relative to the peak area of morphine.

[Peter Apps]

The molecular formulas of the two are the same, and so the FID response per unit mass or mole will be very similar if not identical.

Peter

[AICMM]

This is the perfect example of an application that would be solved by the use of a PolyArc reactor.

Best regards,

AICMM