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- Posts: 78
- Joined: Tue Sep 13, 2022 1:09 pm
We are using currently using:
Purge solvent:
90:10 (v/v) water:methanol + 0.1% formic acid
Needle wash (exterior of needle):
25:25:25:25 water:methanol:acetonitrile:2-propanol + 0.1% formic acid ("Magic Mix")
with 20 seconds of both pre- and post- needle wash and still experiencing carryover issues.
Any suggestions for better needle wash solvent mixtures to try or additional settings on the FTN injector?
(We can't really increase the "purge" solvent strength, because that remains in the needle, is part of the next injection, and will degrade the chromatographic separation.)














 
																							
