Gaussian skim, Tangential skim,

[sana_sankar]

Hai I am back. Finally I could develop a peak detection program. It was a good experience. Thanks chromforum for initial input.

Now I am planning to develop my software.


I frequently come across the following terms, in some jourals


1. Gaussian skim
2. Tangential skim
3. Exponential skim

What do they indicate. How does it affect peak detection?.Is it possible to implement in my software?

[tom jupille]

Before "reinventing the wheel", read Dyson's book on integration techniques:
http://www.amazon.com/Chromatographic-I ... 212&sr=8-1

[aceto_81]

skims is the way the software integrates your peak, it doesn't affect your peak detection, but it affects the area.
When 2 peaks are partially overlapped, you can use one of the mentioned techniques to estimate the area of your peaks.
Instead of making a drop down from the valley between the peaks, the software estimates the peak shape, and calculate according to this the peak area.

Glad to hear that you developed a peak detection program.
Any chance to share some algorithms?
I made-up a script a while ago to process MS data according to the CODA algorithm. It basically smooth outs the baseline, and then calculates scores / extracted mass.
The idea is to screen rapidly your MS data for unknown components, by keeping the relevant channels instead of using a TIC plot which can be very noisy.

Ace

[DR]

Before "reinventing the wheel", read Dyson's book on integration techniques:
http://www.amazon.com/Chromatographic-I ... 212&sr=8-1

and if it is not included in the above, check Waters' Apex Tracking algorithm white paper (at Waters.com).