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HCl in MS
Posted: Thu Oct 13, 2022 12:44 pm
by Mike H.
Can HCl be successfully used in MS?
Re: HCl in MS
Posted: Thu Oct 13, 2022 2:03 pm
by Steve Reimer
Is there an LC or GC in front of this MS?
Re: HCl in MS
Posted: Fri Oct 14, 2022 3:19 pm
by Mike H.
I should have given more information. We have a Agilent 1260-Agilent 6530 QTOF.
I'm curious to known why nobody seems to use HCl to as a MS MP additive.
ty
Re: HCl in MS
Posted: Fri Oct 14, 2022 4:53 pm
by DR
To rephrase - people generally don't want to use anything in a MSD that will leave a salt residue on evaporation.
HCl would be harder on a system than most things...
Re: HCl in MS
Posted: Thu Oct 20, 2022 10:24 am
by lmh
Can't be sure, but I'd strongly, strongly discourage it. Chloride's pretty awful for stainless steel, chloride salts will precipitate; I don't know which I'd feel least happy about, producing chlorine or HCl fumes to run through my delicate MS and vacuum pump.