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HPLC/PDA advantages over GC/MS

http://www.chromforum.org/viewtopic.php?t=11732

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HPLC/PDA advantages over GC/MS

Posted: Tue Nov 17, 2009 12:34 am
by offroad
Dear friends...

What are the advantages of an HPLC/PDA compared to a GC/MS?

If I already have a GC/MS/FID/TCD, what would make me buy an HPLC/PDA/RI?

Thank you

Posted: Tue Nov 17, 2009 11:16 am
by grzesiek
What if the stuff you want to analyse is not volatile?

Posted: Tue Nov 17, 2009 12:03 pm
by offroad
yes, of course, but.... besides the obvious, I thought it had something to do with the fact that some compounds are poorly identified by a GC/MS and then a HPLC/PDA would fit better. I don't know, maybe the analyte needs a much longer column to separate into simple compounds etc.

Anyways, thank you.

Posted: Tue Nov 17, 2009 11:22 pm
by tom jupille
Not much beyond the obvious. :wink: HPLC developed partly in response to the fact that most organic compounds are not sufficiently volatile/thermally stable to be done by GC.
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