Purine compound stability in solution
Posted: Sun Sep 20, 2009 7:46 pm
Hi,
I am trying to increase solution stability of one of the purine compound in 0.1% formic acid. This compound creates a degradation product due to the oxidation ( i believe based on forcedegs). I am trying to find if there are any anti oxidants to add to the solution to stabilize this compound. I tried ascorbic acid but this is interfering with one of the impurity.
wavelength: 260nm
mobilephase: methanol and 0.1% formicacid gradient
Any ideas will be greatly helpful.
Thanks
I am trying to increase solution stability of one of the purine compound in 0.1% formic acid. This compound creates a degradation product due to the oxidation ( i believe based on forcedegs). I am trying to find if there are any anti oxidants to add to the solution to stabilize this compound. I tried ascorbic acid but this is interfering with one of the impurity.
wavelength: 260nm
mobilephase: methanol and 0.1% formicacid gradient
Any ideas will be greatly helpful.
Thanks