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I have slightly lower results from method one compared to method two, what reasons can cause this difference?
Method 1 - 1 tablet into 25mL and follow procedure
Method 2 - 4 tablets into 100mL and follow procedure
There is no apprent extraction or stability problems.

In USP <905> it mentions about SPECIAL PROCEDURE for content uniformity and using a correction factor. Is this for situations like what I am experiencing?
Ranjith

data?

How did you measure your solvents? how much did they weight?

I'll add to the chorus: :wink:

How much different? How many replicates of each procedure? What is the standard deviation for each procedure?
-- Tom Jupille
LC Resources / Separation Science Associates
tjupille@lcresources.com
+ 1 (925) 297-5374
4 posts Page 1 of 1

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