Page 1 of 1
sulphate/sulphate with ri detector
Posted: Fri Sep 11, 2009 8:45 am
by mkatsiabani
Hi!
does anyone know a method for sulphate/sulphite with RI detector?
thank u!
Posted: Fri Sep 11, 2009 11:50 am
by chromSep
Hi!
why you want RI method?
are you working on Topiramate sulphate/sulphamate impurities?? there exist methods employing anion ex. separation of sulphate / sulphamate, followed by negative polarity mode-UV detection.
Re: sulphate/sulphate with ri detector
Posted: Fri Sep 11, 2009 6:44 pm
by Bruce Hamilton
Hi!
does anyone know a method for sulphate/sulphite with RI detector?
thank u!
We require much more information. generally RI will be unsuitable because of their low sensitivity and isocratic solvent modes for trace concentrations.
Bruce Hamilton
Posted: Fri Sep 11, 2009 8:20 pm
by mardexis
You can probably use an ion exclusion column with water mobile
phase and an RI detector. They are available through any number of vendors. Call one of them and ask if the two components separate
on a hydrogen form column.
Posted: Sat Sep 12, 2009 4:02 pm
by mkatsiabani
hi!I want this method for topiramate sulphate/sulphamate in order to avoid conductivity detector because of its low sensitivity.
Posted: Mon Sep 14, 2009 8:52 am
by Markus Laeubli, Metrohm
I do not see any chance to get better sensitivity by using RI instead of conductivity detection.
Which sulfate / sulfamate concentrations are you looking for?
Posted: Tue Sep 15, 2009 7:50 am
by mkatsiabani
the concentrations of sulpahte/sulphamate are 200 ppm each.
Posted: Tue Sep 15, 2009 8:08 am
by mkatsiabani
sorry.10 ppm is the concentration for both sulphate/sulphamate.
Posted: Tue Sep 15, 2009 12:26 pm
by Markus Laeubli, Metrohm
I have seen applikations in this range from Metrohm India
METROHM INDIA LIMITED
NO.13, 1ST AVENUE,
INDIRA NAGAR,
ADYAR,
CHENNAI - 600 020
(91) 44 24410444 / 24452726
(91) 44 24430384
info@metrohm.in
Please check with them and ask for Deepak Parab.