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discontinuous in peaks detection!!
Posted: Wed Aug 19, 2009 10:38 pm
by che313
In our agilent 5975 which is start detection after 2 min for solvent delay he stopped the detection at time 4 min then redetect again at time 9min to the end at time 16 min!!!
what could be the reason is? filment or software issue?
Posted: Thu Aug 20, 2009 1:40 am
by Don_Hilton
Check your MS method. I believe that you can lower the sensitivity of an Agilent MS during the run. This is handy for runs with large solvent peaks mid-run. (I've not touched an Agilent MS for a few years, so I can't give you exact details. I expect another user to join in soon...)
Posted: Thu Aug 20, 2009 3:00 pm
by AICMM
che313,
I can think of two things. First, as Don_Hilton said, you have timed events that are adjusting the EM or filament. Look under the MS scan/sim parameters for timed events table. The other possibility is you have it set up for SIM and in certain ranges you switch ions and they are not abundant (for example you changed target components) so the baseline drops way down. Obviously does not apply if you are running scan mode....
Best regards.
Posted: Thu Aug 20, 2009 4:17 pm
by Ron
Another possibility is that there are no analytes of interest in that region, so no data is collected during that time period. This is pretty common in SIM runs where there are only a few target analytes.