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PAH analysis with LC-ESI-MS/MS
Posted: Tue Dec 29, 2020 1:10 pm
by Silvrie
I am searching the way to analyze PAH compounds with LC-ESI-MS/MS. Is that any method that related to ESI? Because most of the papers that I read is using APPI or APCI. Thank you
Re: PAH analysis with LC-ESI-MS/MS
Posted: Wed Dec 30, 2020 1:17 am
by Steve Reimer
ESI won't ionize PAHs very well which is why APPI is normally used. Or GC/MS.
Re: PAH analysis with LC-ESI-MS/MS
Posted: Wed Dec 30, 2020 8:58 pm
by James_Ball
I tried ESI and didn't get much better sensitivity than on a DAD, though you can lose some of the interfering background. GCMS in SIM mode or GCMSMS are the way to go for PAH.
Re: PAH analysis with LC-ESI-MS/MS
Posted: Thu Dec 31, 2020 7:46 pm
by dblux_
HPLC/FLD forgotten by all posters ?
Re: PAH analysis with LC-ESI-MS/MS
Posted: Sat Jan 02, 2021 4:36 pm
by JMB
As an alternative, you can try post-column addition of a solution of a metal salt.
I have used AgBF4 in MeCN to detect Vit. D3 and esters.
Regards,
JMB
Re: PAH analysis with LC-ESI-MS/MS
Posted: Mon Jan 04, 2021 8:16 pm
by James_Ball
HPLC/FLD forgotten by all posters ?
I have ran samples with FLD/DAD in tandem, and it is great and super sensitive, but only works for clean samples. If the sample is a dirty soil, good luck finding the PAH from the other junk.
FLD/DAD for drinking water and clean well or waste water, but GCMS for the dirty samples.