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Accetable retention time drift for system suitability?

Posted: Sun Oct 25, 2020 6:56 pm
by chemist23
What are acceptable limits for retention drift in LC for system suitability requirements?

I seen some such as 2%,5% and even 10% difference. What is the most common?

Re: Accetable retention time drift for system suitability?

Posted: Sun Oct 25, 2020 8:37 pm
by tom jupille
No single answer to that. Among other things, it depends on the resolution of your analytes from interferences. As a broad generalization, it should be small enough to prevent mis-identification of peaks.

Re: Accetable retention time drift for system suitability?

Posted: Mon Oct 26, 2020 3:03 pm
by pwm
For our OQPQ it is NMT 0.3%RSD on six replicates of caffiene.