That's the "fallback" error-trapping routine. It means that the data you have entered have generated a math error (e.g., division by zero, log of a negative number, etc.). I spent 15 years doing tech support for the program. Over that period the most common cause was typographical errors entering data. Second most common was incorrect dwell volume (for gradient data). Third most common was insufficient equilibration time between calibration runs. Fourth was "unusual" chromatographic behavior (severe non-linearity). And, there were the occasional bugs (which the programmers were very good about fixing!)

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The first thing you should do is to check that you are using the latest version of DryLab. Click on Help . . . About to see the current version number, then go to the Rheodyne web site (sponsor link in the upper right-hand corner of the Forum, or:
http://www.rheodyne.com). Click on
Products . . . Chromatography Software . . . Latest Release.
If you are in North America, call 1-800-4drylab [1-800-437-9522] and ask for technical support. If you're outside North America, send me an e-mail (address below). Although I no longer work for Rheodyne, I still have a copy of the program, and I'll see what I can do.