Interesting paper in Chromatographia re: formic acid MP's
Posted: Fri May 15, 2009 1:26 pm
Journal: Chromatographia
Publisher: Springer-Verlag
Title: Peculiarities of Mobile Phases Containing Formic Acid
Author(s) Eric Loeser
DOI 10.1365/s10337-009-1001-7
Online since February 05, 2009
Page 807 - 811
It describes how formic acid acts as a co-solvent in highly aqueous MP's due to the fact that only a small percentage of the formic acid in solution is actually dissociated. Also it describes desolvation during acetonitrile gradients, causing a spike (low UV) at the beginning of such gradients.
Not rocket science, certainly but I think something to be aware of for practicing chromatographers.
Publisher: Springer-Verlag
Title: Peculiarities of Mobile Phases Containing Formic Acid
Author(s) Eric Loeser
DOI 10.1365/s10337-009-1001-7
Online since February 05, 2009
Page 807 - 811
It describes how formic acid acts as a co-solvent in highly aqueous MP's due to the fact that only a small percentage of the formic acid in solution is actually dissociated. Also it describes desolvation during acetonitrile gradients, causing a spike (low UV) at the beginning of such gradients.
Not rocket science, certainly but I think something to be aware of for practicing chromatographers.