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Compare two different analytical methods
Posted: Mon Jun 15, 2020 6:38 pm
by nbellora
Hi at all,
i have made two different methods (one with Helium and the other with Hydrogen), i have calibration curves with a good R2 and i quantify the same compounds in both. My problem is that tha compounds quantification its's different in the two methods, but the calibration curve are good.
I don't know how to compare statistically the two methods.
suggestions?
thanks
Re: Compare two different analytical methods
Posted: Mon Jun 15, 2020 7:52 pm
by dap
General answer: Fisher's F-test & Student's t-test.
Re: Compare two different analytical methods
Posted: Tue Jun 16, 2020 11:35 am
by larkl
Re: Compare two different analytical methods
Posted: Tue Jun 16, 2020 9:55 pm
by James_Ball
Hi at all,
i have made two different methods (one with Helium and the other with Hydrogen), i have calibration curves with a good R2 and i quantify the same compounds in both. My problem is that tha compounds quantification its's different in the two methods, but the calibration curve are good.
I don't know how to compare statistically the two methods.
suggestions?
thanks
Are you saying unknown samples are giving different results or the calibration standards have different results when quantified against the curve?
Is there 1% difference or 20% difference between the Helium and Hydrogen results?
Re: Compare two different analytical methods
Posted: Wed Jun 17, 2020 8:22 pm
by nbellora
The calibration curve in both it's good (R2 and accuracy are perfect). But the samples are different from 1% for triacetin and 20% for phenol.
I don't know if it is due to a different sensitivity of the two method.
I want to calculate LOD and LOQ of two methods and maybe made a sample with spike.