which solvents are universal solvents for rinsinng in MS
Posted: Thu Apr 23, 2009 6:22 am
Dear all,
I am working on LC-MS/MS and performing validation of NCE, i have tried differant types of rinsing solvents to avoid the carryover, finally i have fixed one ratio of rinsing solvent which i find good and working for my NCE without carryover but on long term this rinsing solvent have drop the response to 10 times so i want rinsing solvent without carryover and which will not affect the sensitivity; can anyone will suggest which solvent will we have to prefer to overcome the problem;
if i have tried ACN:Acetone:IPA.
which solvents are universal solvents for rinsinng in MS
without affecting response and carryover issues.
Regards,
Sadanand Mallurwr
Research Associate,DMPK
Luoin Research park,Pune
I am working on LC-MS/MS and performing validation of NCE, i have tried differant types of rinsing solvents to avoid the carryover, finally i have fixed one ratio of rinsing solvent which i find good and working for my NCE without carryover but on long term this rinsing solvent have drop the response to 10 times so i want rinsing solvent without carryover and which will not affect the sensitivity; can anyone will suggest which solvent will we have to prefer to overcome the problem;
if i have tried ACN:Acetone:IPA.
which solvents are universal solvents for rinsinng in MS
without affecting response and carryover issues.
Regards,
Sadanand Mallurwr
Research Associate,DMPK
Luoin Research park,Pune