Chromatography Forum

Hello,

I am looking for a good solution for the integration of peaks in the GC-FID / MS system.
This is a (semi-quantitative) screening method, the result calculated based on ISTD from FID and identification based on mass spectrum.
Agilent software is not very helpful in this situation.

The only way to do a "non target" type analysis would be to use Area% which would rank the peaks by % of the area of the largest peak. To get something in concentration you have to set up the target in the quant database and reference it to at least one calibration standard.

The MS Library search will so a semi quant on search hits if you set up an internal standard in a quant database and quant the chromatogram so that it has a reference to the internal standard then it will use a response factor of 1 to estimate concentrations of the hits, but that doesn't work for the FID chromatogram.

What type of sample and expected targets are you looking to quantify?

What type of sample and expected targets are you looking to quantify?

Additives for plastics, their decomposition products, substances added non-intentionally, hydrocarbons.
For now, I use Unknow Analysis or Qual, and then manually integrate FID responses. Using FID I receive much higher concentration accuracy compared to MS.