Chromatography Forum

If you have a Thermo TSQ Quantum GC QQQ mass spectromter, some of their representitatives (some with Ph.D. education) should have told you when you input the mass value, you must be accurate to the second decimal (eg. m/z 118.88, not 119, nor 118.9), and use a mass scan window of 0.01 amu or less, or you lose both sensitivity and stability. This claim is, without doubt, beyond the resolution power of a classic quadrupole.

However, one person in my lab had some tests, and did find signal increase. Is it just a random coincidence, or faith works? but, it also means you may have to update your mass everytime you run the method.

Any opinion on this?

My lab got a TSQ Quantum Discovery. The engineer only told me to set the mass ion to one decimal place. Scan window is set down to 0.01 Da for better specificity, if necessary. Nothing to deal with sensitivity.