dioxane from cosmetic??

[che313]

Newspaper posted that some of commercail shampoo availble in the local market are carcogenic. I look about this issue in the internet and found that the material may be 1,4-dioxane. I bought those shampoo and would like to test it. I thought it could be done by headspace technology. Any body work with this case before?

[krickos]

Hi

Not with dioxane in shampoo but in pharmaceuticals and used headspace then.
You have an intresting sample matrix so I would suggest that you use standard addition to quantify dioxane.

Personally I would likely start with adding 0,5000-1,0000g of a sample directly to a HS vial and add 1-4,0ml of water and compare with a pure water based standard.

Dioxane has a bp of around 100°C if recalling right so a headspace temperature of 60-70°C would likely be a good start.

[Consumer Products Guy]

Use headspace GCMS, we've done that here. Dioxane at trace levels is present whenever ethoxylated materials are used, sucha s most nonionic surfactants. Suppliers use vacuum stripping to keep the dioxane levels low in their raw materials, but some always remains.

[AICMM]

Am I wrong, or is dioxane wickedly hard to get out of water for headspace? K value of 1618 according to table in Restek guide. Is there a better solvent to use for this application?

Best regards.

[krickos]

Am I wrong, or is dioxane wickedly hard to get out of water for headspace? K value of 1618 according to table in Restek guide. Is there a better solvent to use for this application?

Best regards.

Hi

Possibly, however digged in the archive while I was roamining it for something else and found an old method for dioxane:

In short: a DB-624 column (30m*0,32mm* 1,8um ) split ratio about 10. HS oven at 60°C. Sample/std vials (10ml) all contained 1g of sodiumsulfat (hmm a bit over the top i think to get a salt out effect). The std solution in std vial was 5ml containing a total of 10ug dioxane.

Not the nicest/biggest peaks if recalling right but clearly visible.