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Posted: Fri May 20, 2005 12:38 pm
by ltnguy3
Zompa,
I haven’t worked on this method lately because I’ve had to develop another method for different product. I will go back to the zoledronic method by late June. I will let you know if I get any good separation.
Posted: Mon May 30, 2005 4:17 pm
by Fernando
Hello Itnguy 3
I have started with Zoledronic acid using a PRP-X200 anion exchanger but I obtained one peak (ZA+Citrate+Mannitol), I would like to have your article my e-mail is:
fyamin@hotmail.com
Thanks!
Posted: Thu Jun 02, 2005 4:17 pm
by Fernando
Sorry Iavi
I can´t download that .pdf, yes I have the Acrobat Reader. Thanks all the same!!!
Posted: Fri Jun 03, 2005 4:33 pm
by Kazimierz
Posted: Thu Jun 09, 2005 11:42 am
by Fernando
Hi All
I´ve tried with a RP-18 Luna (250 x 4.6 mm) at 45 degrees, with a mobile phase consisting of a solution of triethylammonium cloride 40 mM + 0.2 % phosphoric acid-Methanol [90:10]. Good separation of ZH and the rest, good placebo run!
I would like to konw of your experiences.
Posted: Tue Jun 21, 2005 10:58 am
by hocka
You may try another ion-pair reagent, example 4 mM tetrabutyl-ammonium-hydroxid (this is a kation and your molecule is acid) solution as eluent.